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esterified estrogens with methyltestosterone (ESTRATEST, ESTRATEST HS)

Drug and Dietary Supplement Profiles

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
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Disease and Drug Family Information

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  • Hormone Replacement Therapy [hide all summaries]
    In 1991, the Health Research Group published the Women’s Health Alert. The largest chapter in the book was on hormone replacement therapy (HRT). By then, the evidence was clear that these drugs caused breast cancer, and very serious doubts had been raised about their ability to protect against heart disease. The first sentence in this chapter began: Female replacement hormones may someday be remembered as the most recklessly prescribed and dangerous drugs of this century.

Worst Pills, Best Pills Newsletter Articles

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  • Quality of Drug Prescribing [hide all summaries]
    (March 2011)
    The article reviews a study on the potentially dangerous, inappropriate prescribing of 77 drugs that pose a high risk to older adults. Of the 67 of these drugs that we had previously reviewed in Worst, Pills, Best Pills News, we had classified 60 (90 percent) of them as “Do Not Use,” and the other seven as "Limited Use."
  • DO NOT USE! Esterified Estrogens With Methyltestosterone (ESTRATEST and ESTRATEST HS) For Hot Flashes [hide all summaries]
    (August 2003)
    On April 10, 2003, the Food and Drug Administration (FDA) announced that it was beginning legal procedures to remove the marketing authorizations for combination drug products containing estrogen and androgen, female and male hormones respectively. Estrogen and androgen combination products had been approved for the treatment of moderate to severe “hot flashes” (vasomotor symptoms) associated with the menopause in women whose symptoms were not improved by estrogen alone. We agree with the FDA’s decision to remove the marketing authorizations for combination drug products containing estrogen and androgen; however, the issue over the effectiveness of these combinations goes back for decades and this action by the FDA is long overdue.

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