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  • Preserving Bones with Bisphosphonates: Should You Avoid NSAIDs? [hide all summaries]
    (July 2010)
    It appears likely that patients who take bisphosphonates (such as FOSAMAX) and NSAIDs at the same time have an increased risk of gastrointestinal ulcers as opposed to taking either drug alone. The article reviews the studies demonstrating this and offers some practical advice on what the cautious drug user should do.
  • Death of Parts of the Jaw Bone With Osteoporosis Drugs Such As Alendronate (FOSAMAX) [hide all summaries]
    (September 2006)
    The typical signs and symptoms of osteonecrosis of the jaw may include pain, swelling or infection of the gums, loosening of the teeth, poor healing of the gums, numbness or a feeling of heaviness in the jaw, drainage and exposed bone. Patients taking a bisphosphonate (including Fosamax) should carefully monitor themselves for any sign of jaw problems resembling those described in this article.

Additional Information from Public Citizen

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  • [hide all summaries]
    Long-term use of bisphosphonates for the prevention of osteoporotic fractures must be limited to 5 years, and the indication for bisphosphonate treatment for osteopenic women must be removed, unless the patient has a significant 10-year fracture risk as determined by the World Health Organization’s (WHO) FRAX algorithm.

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