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tanezumab (HETLIOZ)

Additional Information from Public Citizen

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    The Food and Drug Administration (FDA) should reject the recommendation of the Arthritis Advisory Committee to resume clinical development of anti-nerve growth factor drugs for management of chronic pain. Further human studies of these drugs would be unethical and not approvable under FDA regulations for the protection of human subjects because the risks outweigh the potential benefits to subjects and the importance of the knowledge that is expected to result.
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    We strongly urge the Food and Drug Administration (FDA) to permanently suspend the clinical development of these anti-nerve growth factor (anti-NGF) agents for the treatment of pain because of the dramatic safety signal seen in clinical studies of these agents demonstrating an unusually high incidence of rapid joint destruction.

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