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pioglitazone (ACTOS)

Drug and Dietary Supplement Profiles

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
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Disease and Drug Family Information

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  • Diabetes Prevention and Treatment [hide all summaries]
    Diets that are very complicated or very different from what you are used to are hard to follow. The American Diabetes Association (ADA) diet is a highly structured plan based on exchange lists. Although it serves its purpose of regulating calorie and sugar intake quite well, the ADA diet may be difficult for older people to use. Successful use of this diet requires considerable time spent planning meal patterns and food portions. Older people often have trouble with this diet because the food lists are long and complicated and require considerable memorization.

Worst Pills, Best Pills Newsletter Articles

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Additional Information from Public Citizen

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  • [hide all summaries]
    We urge the FDA to halt an international diabetes trial that would put patients at unnecessary risk.
  • [hide all summaries]
    Dr. Wolfe explains why the TIDE study must be stopped immediately, and pushes the FDA to ban rosiglitazone (Avandia).
  • [hide all summaries]
    The Food and Drug Administration (FDA) knew nearly five years ago about the dangers associated with the diabetes drug Avandia, an internal FDA memo shows.
  • [hide all summaries]
    However, drug company websites are not the only, and certainly not the best, place to find unpublished data on drugs. Consulting readily available US governmental sources on the internet can lead to different conclusions regarding drug safety and efficacy. Using FDA data sources, we have just completed our own assessment of the thiazolinediones.
  • [hide all summaries]
    Class efficacy issues include the lack of efficacy compared to previously available drugs, sulfonylureas, and the deterioration of blood sugar levels when patients are switched from other oral anti-diabetic drugs to the glitazones. Safety issues include liver toxicity, effects on heart function, weight gain, edema, anemia, low blood pressure, elevated lipid levels, and possible changes in progesterone levels.

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