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rosiglitazone (AVANDIA)

Drug and Dietary Supplement Profiles

A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
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Disease and Drug Family Information

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  • Diabetes Prevention and Treatment [hide all summaries]
    Diets that are very complicated or very different from what you are used to are hard to follow. The American Diabetes Association (ADA) diet is a highly structured plan based on exchange lists. Although it serves its purpose of regulating calorie and sugar intake quite well, the ADA diet may be difficult for older people to use. Successful use of this diet requires considerable time spent planning meal patterns and food portions. Older people often have trouble with this diet because the food lists are long and complicated and require considerable memorization.

Worst Pills, Best Pills Newsletter Articles

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Additional Information from Public Citizen

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  • [hide all summaries]
    Public Citizen argues that not only should the current restrictions on the use of the diabetes drug rosiglitazone (Avandia) not be lifted, the drug should be removed from the U.S. market given its unique risks and the absence of any unique benefits. Among older patients with diabetes, rosiglitazone is associated with a significantly higher risk of heart failure and death compared to pioglitazone.
  • [hide all summaries]
    Late yesterday, the FDA faxed Public Citizen its letter rejecting our October 30, 2008 petition in which we asked the FDA to ban rosiglitazone (Avandia) because its benefits were greatly outweighed by its multiple risks, including increased heart attacks, heart failure, fractures, vision-threatening macular edema and other serious problems.
  • [hide all summaries]
    The Food and Drug Administration (FDA) has gone only half-way in stopping the unethical TIDE study by halting the recruitment of any new patients. To allow the experiment to continue at all is a major breach in the FDA’s obligation to protect people in clinical trials.
  • [hide all summaries]
    Rosiglitazone (Avandia) compares unfavorably to Pioglitazone (Actos) and should be removed from the market.
  • [hide all summaries]
    We urge the FDA to halt an international diabetes trial that would put patients at unnecessary risk.
  • [hide all summaries]
    Dr. Wolfe explains why the TIDE study must be stopped immediately, and pushes the FDA to ban rosiglitazone (Avandia).
  • [hide all summaries]
    In contrast to becoming more active and cautious in enhancing food safety by removing potentially dangerous products before they have caused harm, several FDA decisions in the past year regarding prescription drugs can only be described as reckless.
  • [hide all summaries]
    WASHINGTON, D.C. - New research by Public Citizen published today in a peer-reviewed medical journal reinforces the case that the diabetes drug Avandia can cause death from liver failure and should be banned immediately by the Food and Drug Administration (FDA).
  • [hide all summaries]
    The Food and Drug Administration (FDA) should immediately ban the dangerous diabetes drug Avandia because it can cause death from liver failure and has many other life-threatening risks that far outweigh its benefits.
  • [hide all summaries]
    The popular type 2 diabetes drug Avandia should be removed from the U.S. market, according to testimony delivered today by Public Citizen before a Food and Drug Administration (FDA) advisory committee panel investigating the medication.
  • [hide all summaries]
    The Food and Drug Administration (FDA) knew nearly five years ago about the dangers associated with the diabetes drug Avandia, an internal FDA memo shows.
  • [hide all summaries]
    Statement by Sidney Wolfe, MD, Director of Health Research Group at Public Citizen
  • [hide all summaries]
    However, drug company websites are not the only, and certainly not the best, place to find unpublished data on drugs. Consulting readily available US governmental sources on the internet can lead to different conclusions regarding drug safety and efficacy. Using FDA data sources, we have just completed our own assessment of the thiazolinediones.
  • [hide all summaries]
    Class efficacy issues include the lack of efficacy compared to previously available drugs, sulfonylureas, and the deterioration of blood sugar levels when patients are switched from other oral anti-diabetic drugs to the glitazones. Safety issues include liver toxicity, effects on heart function, weight gain, edema, anemia, low blood pressure, elevated lipid levels, and possible changes in progesterone levels.

Health Letter Articles

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  • Improving Public Access to Clinical Trial Information [hide all summaries]
    (September 2007)
    Clinical trials databases can disclose that a trial is taking place and the results of the trial once it is completed. Our international study of such databases shows that only a government-run database is likely to produce a comprehensive, consumer-friendly database.

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